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KMID : 0386319850180010051
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Korean Leprosy Bulletin
1985 Volume.18 No. 1 p.51 ~ p.55
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The Hepatotocity of Multi-Drug Therapy With Prothionamide for Multibacillary leprosy Patients
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Abstract
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LFT abrlormality was observed in 11 of 58 multibacillary leprosy patients treated with
combinations of isoprodian daily adminstered and rifampicin＋clofazlmine monthly
supervised The drug responsible for hepatotoxisity waIn probably prothionamide,
although rifampicin may have been a risk factor. Due to the high incidence of
heptotoxicity it is necessary to perform the liver function test monthly in the initial
1-year course of MDT containing prothionamide.
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KEYWORD
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